Henry married Matilda Ann Ambrose on October 21, 1852. According to his obituary in the Ligonier Echo, he died "after a lingering illness of stomach trouble" on July 11, 1896. His will was filed and probated on July 16, 1896. His son, Ambrose M. Karns, was executor. Witnesses were Harrison H. Galbreath, my great-great-uncle, and Harry B. Albright.
He is buried in Ligonier Valley Cemetery.
Children of Henry Karns and Matilda Ann (Ambrose) Karns:
- William Henry Karns, born February 19, 1854; died December 15, 1876.
- Christina Lucinda Karns, born September 18, 1855, Ligonier, Pennsylvania; married Adam Mitchell, 1876, Anthony Nicely, 1910; died April 11, 1935, Ligonier, Pennsylvania.
- Sarah Karns, born August 7, 1860, Ligonier, Pennsylvania; married William H. Ferry, September 20, 1877, Ligonier; died February 11, 1919.
- Ambrose Miller Karns, born November 13, 1868, Ligonier, Pennsylvania; married Annetta Noel, February 21, 1888, died August 2, 1932, Vernon, Pennsylvania.